"How can macromolecular interactions be engineered in a rational manner to have the desired effects in a complex environment, such as a living organism?"
Answering this question is a major focus of much of the work
carried out in the Green Lab. The interactions between biological
macromolecules, and particularly proteins, play a fundamental role in
biology, and while we have learnt a great deal about these
interactions on many levels, our understanding is not yet at the level
needed for the robust engineering of novel macromolecules. We are
working on multiple fronts: to push forward the level of general
understanding of biomolecular interections; to develop novel
computational tools for the study and design of interacting
macromolecules; and to directly apply our expertise to the rational
design and engineering of proteins with real-world applicablity.
A major focus is on answering questions related to
Our choice of methods to solve these problems are primarily
the tools of computational biology. We employ a range of models and
computational methods, including:
Additionally, we currently are beginning an experimental component to our work, expressing, purifying and characterizing proteins which we have designed through rational computer-aided engineering.
The Green Lab is an actived member of a number of interdisciplinary
groups that bring together scientists from a range of Stony Brook
departments, as well as individuals at Brookhaven National Laboratory.
For students interested in graduate study, we are affiliated with
several graduate programs which suit students from diverse
backgrounds. We are additionally affiliated with summer research
programs for undergraduates and high-school students who are
interested in gaining hands-on experience in research.
This page is maintained by David F. Green <email@example.com>. Last updated: Tue Jan 10 12:19:48 2012Copyright © 2003–2009 David F. Green.
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