MLOD : A Program for Maximized LOD score calculation
for nuclear families
Program
The package includes the following files:
Instructions: How to run MLOD
MLOD.exe runs on Microsoft Windows 95, 98, NT, 2000, ME, XP and Vista (all 32bit system). MLOD can be run in MS-DOS command line mode, or in Windows mode using a batch file.
To run MLOD, run MLOD.exe file in command line followed by the input and output data file names:
>MLOD [input file] [output file]
Running MLOD in command line mode
Open a MSDOS command window. This can most likely be found on your computer under 'Start -> All Programs -> Accessories -> Command Prompt'
At the prompt, type the command 'chdir' followed by the full path name of the folder in which you saved the MLOD program, and press enter
At the new prompt, which should now include the correct path name, type 'MLOD inputfile.txt outputfile.txt' and press enter if input and output file names are inputfile.txt and outputfile.txt.
The program will take a few minutes to run and, upon completion, will save the output as 'outputfile.txt' in the same folder in which the input file and MLOD program are located.
Running MLOD by creating a batch file
If you create a batch file containing the command lie to run MLOD, you can run MLOD in the windows mode without opening MS-DOS command window.
Using a text editor program (e.g. Notepad), create a text file containing the command line to run MLOD (e.g. 'MLOD inputfile.txt outputfile.txt'), then save the file as batch.bat. Make sure that the file extension is '.bat'.
Copy input data file in the directory where MLOD is saved.
Double click 'batch.bat'. Upon completion, the output file 'outputfile.txt' will be saved in the same directory.
Note that you the command window will be closed upon completion of batch mode. You cannot monitor the error message or screen output once it is closed.
Program History
- July 25, 2007: the program is released.
- Jan 1, 2008: the program is upgraded to control the number of iterations by users.
- Mar 1, 2008: the program is upgraded to incorporate missing genotypes and phenotypes.
- May 12, 2008: bug fixed - machine dependent errors due to the precision of variables.
References
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Yun Joo Yoo and Nancy R. Mendell (2008), The Power and Robustness of Maximum LOD Score Statistics, Annals of Human Genetics, in press.
We are planning to update our program regularly. You are welcome to suggest features
that you want us to implement into this program. We greatly appreciate if you could point out any bugs
when you use our program. Our contact information is:
Nancy R. Mendell, Ph.D.
Department of Applied Math & Statistics
Stony Brook University
Stony Brook, NY, 11794
(631) 632-8373 (phone)
Email: nmendell@notes.cc.sunysb.edu
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or |
Yun Joo Yoo, Ph.D.
Samule Lunenfeld Research Institute
Mount Sinai Hospital
Toronto, ON M5T 3L9
(415) 586-4800 ext. 7538 (phone)
Email: yoo@mshri.on.ca
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Created Date: July 25, 2007
Last Updated Date: May 12, 2008