PARS: Paternal Age Related Schizophrenia

This was a collaboration with the Institute for Social and Psychiatric Initiatives, NYU Langone Medical Center. PARS has been proposed as a subgroup of schizophrenia with distinct etiology, pathophysiology and symptoms. PARS is defined as a group of schizophrenia patients without any family history of schizophrenia among first and second-degree relatives and fathers' age at birth of 35 years or less. This study uses k-means clustering analysis to detect latent subgroups of PARS. Data were available on various demographic variables, positive and negative syndrome scales (PANSS), cognitive tests (Wechsler Audit Intelligence Scales-Revised: WAIS-R) and olfaction (UPSIT). We conducted a serious of k-means clustering analyses to identify clusters of cases containing high concentrations of PARS.

• Publications:
  • Lee, H., Malaspina, D., Ahn, H., Perrin, M., Opler, M. G., Kleinhaus, K., Harlap, S., Goetz, R. and Antonius, D. Paternal age related schizophrenia (PARS): Latent subgroups detected by k-means cluster analysis. Schizophrenia Research, 128, 143-149, (2011). DOI: 10.1016/j.schres.2011.02.006
    
  • Malaspina, D., Keller, A., Antonius, D., Perin, M., Opler, M., Ahn, H., Kleinhaus, K., Messinger, J., Goetz, R. and Harlap, S. Advanced paternal age contributes to a specific subtype of schizophrenia. Schizophrenia Research, S136, 3, (2012). DOI: 10.1016/S0920-9964(12)70011-7
    
  • Walsh-Messinger, J., Jiang, H., Lee, H., Rothman, K., Ahn, H. and Malaspina, D. Relative importance of symptoms, cognition, function and parental ages for psychiatric disease classifications by machine learning. Psychiatry Research, 278, 27-34, (2019). DOI: 10.1016/j.psychres.2019.03.048